RecruitingRecruiting
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT07218341 · Eli Lilly and Company
In plain English
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Official title
Long-Term Safety of Pirtobrutinib in Participants From Study LOXO-BTK-20020 With BTKi Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
About this study
This study will evaluate the long-term safety of pirtobrutinib in participants with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study is open to those who completed J2N-MC-JZNN/LOXO-BTK-20020 (NCT 04666038) for continued access to the study intervention or continued follow-up visits. Treatment will be given every 4 weeks and this study is expected to last about 5 years.
Eligibility criteria
Inclusion Criteria:
* Are actively participating in study J2N-MC-JZNN/LOXO-BTK-20020
Exclusion Criteria:
* This is not applicable to this study
Study design
Enrollment target: 150 participants
Allocation: non_randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2026-03-09
Estimated completion: 2032-12
Last updated: 2026-05-22
Interventions
Drug: PirtobrutinibDrug: Idelalisib
Primary outcomes
- • Percentage of Participants with a Grade 3 or Higher Treatment-emergent Adverse Events (AEs) (Time from First Dose of Study Intervention (Study Day 1) through 30 Days After Last Dose of Study Intervention or Start of New Anticancer Therapy, whichever is Earlier)
Sponsor
Eli Lilly and Company · industry
Contacts & investigators
ContactTrial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · contact · LillyTrials@Lilly.com · 1-317-615-4559
ContactPhysicians interested in becoming principal investigators please contact · contact · clinical_inquiry_hub@lilly.com
InvestigatorCall 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · study_director, Eli Lilly and Company
All locations (53)
Mitchell Cancer InstituteNot Yet Recruiting
Mobile, Alabama, United States
Arizona Oncology Associates, P.C. - HOPENot Yet Recruiting
Tucson, Arizona, United States
Cancer Specialists, LLCNot Yet Recruiting
Jacksonville, Florida, United States
Minnesota Oncology Hematology, P.A.Not Yet Recruiting
Coon Rapids, Minnesota, United States
Cayuga Cancer CenterNot Yet Recruiting
Ithaca, New York, United States
Memorial Sloan-Kettering Cancer Center (MSKCC) - New YorkRecruiting
New York, New York, United States
Oncology Hematology Care IncNot Yet Recruiting
Cincinnati, Ohio, United States
Texas Oncology - ParisNot Yet Recruiting
Fort Worth, Texas, United States
US Oncology - Texas OncologyNot Yet Recruiting
Kyle, Texas, United States
Liverpool HospitalNot Yet Recruiting
Liverpool, Australia
The Alfred HospitalNot Yet Recruiting
Melbourne, Australia
LKH - Universitätsklinikum der PMU SalzburgNot Yet Recruiting
Salzburg, Austria
AZ DeltaNot Yet Recruiting
Roeselare, Belgium
Princess Margaret Cancer Centre - University Health NetworkNot Yet Recruiting
Toronto, Canada
Xuanwu Hospital Capital Medical UniversityNot Yet Recruiting
Beijing, China
Hunan Cancer HospitalNot Yet Recruiting
Changsha, China
Sun Yat-sen University Cancer CenterNot Yet Recruiting
Guangdong, China
Nanfang Hospital of Southern Medical UniversityNot Yet Recruiting
Guangzhou, China
Gansu Provincial Cancer HospitalNot Yet Recruiting
Lanzhou, China
The First Affiliated Hospital of Nanchang UniversityNot Yet Recruiting
Nanchang, China
Fudan University Shanghai Cancer CenterNot Yet Recruiting
Shanghai, China
Taizhou Hospital of Zhejiang ProvinceNot Yet Recruiting
Taizhou, China
Hematology Hospital of the Chinese Academy of Medical SciencesNot Yet Recruiting
Tianjin, China
Tianjin Medical University Cancer Institute & HospitalNot Yet Recruiting
Tianjin, China
Affiliated Cancer Hospital of Xinjiang Medical UniversityNot Yet Recruiting
Ürümqi, China
The Affiliated Hospital of Xuzhou Medical CollegeNot Yet Recruiting
Xuzhou, China
Henan Cancer HospitalNot Yet Recruiting
Zhengzhou, China
University Hospital Center ZagrebNot Yet Recruiting
Zagreb, Croatia
Fakultni nemocnice Hradec KraloveNot Yet Recruiting
Hradec Králové, Czechia
Centre Henri BecquerelNot Yet Recruiting
Rouen, France
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai IntezetNot Yet Recruiting
Budapest, Hungary
Debreceni EgyetemNot Yet Recruiting
Debrecen, Hungary
St. James's HospitalNot Yet Recruiting
Dublin, Ireland
Beaumont HospitalNot Yet Recruiting
Dublin, Ireland
Azienda Ospedaliero - Universitaria Nazionale Santi Antonio e Biagio e Cesare ArrigoNot Yet Recruiting
Alessandria, Italy
Azienda Ospedaliera Universitaria CareggiNot Yet Recruiting
Florence, Italy
Presidio Ospedaliero PapardoNot Yet Recruiting
Messina, Italy
Fondazione IRCCS San Gerardo dei TintoriNot Yet Recruiting
Monza, Italy
Azienda Ospedaliera di Perugia Ospedale S. Maria della MisericordiaNot Yet Recruiting
Perugia, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCSNot Yet Recruiting
Rome, Italy
Tel Aviv Sourasky Medical CenterNot Yet Recruiting
Tel Aviv, Italy
Azienda Ospedaliera S. Maria Di TerniNot Yet Recruiting
Terni, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo RomaNot Yet Recruiting
Verona, Italy
Tokai University HospitalRecruiting
Isehara, Japan
Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im.ks.B.MarkiewiczaNot Yet Recruiting
Brzozów, Poland
Szpital Uniwersytecki Nr 2 im. dr J. Biziela w BydgoszczyNot Yet Recruiting
Bydgoszcz, Poland
Pratia Onkologia KatowiceNot Yet Recruiting
Katowice, Poland
Instytut Hermatologii I TransfuzjologiiNot Yet Recruiting
Warsaw, Poland
Hospital Universitario Marques De ValdecillaNot Yet Recruiting
Santander, Spain
Hospital Universitario Virgen Del RocioNot Yet Recruiting
Seville, Spain
Castle Hill HospitalNot Yet Recruiting
Hull, United Kingdom
St James's University HospitalRecruiting
Leeds, United Kingdom
GenesisCareNot Yet Recruiting
Newmarket, United Kingdom