RecruitingRecruiting
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
NCT07224490 · Massachusetts General Hospital
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
Delivery of Interventions:
* Administration of a single kisspeptin bolus in a dosing range of 0.313 - 13.19 μg/kg
* Blood sampling before and after administration of kisspeptin (two timepoints total)
Eligibility criteria
Inclusion Criteria
* Female (ages 18-45 years) or Male (ages 18-60 years)
* No current or recent use of a medication (including hormonal replacement) that, in the opinion of a study investigator, can modulate the reproductive axis or willing to complete an appropriate washout for that particular medication and its method of administration
* For women, negative serum hCG pregnancy test
* For cases, diagnosis of post-covid-19 syndrome
* For controls, history of prior covid infection but no diagnosis of post-covid-19 syndrome
Exclusion Criteria
* Any condition (medical, mental, or behavioral) that, in the opinion of a study investigator, would likely interfere with participation in/completion of the protocol or the interpretation of results
* Active use of illicit drugs (not including marijuana)
* For women,
* Pregnant
* Trying to become pregnant during protocol participation
* Breast feeding
* Surgical or natural menopause
Study design
Enrollment target: 40 participants
Allocation: na
Masking: none
Age groups: adult
Timeline
Starts: 2026-03-10
Estimated completion: 2030-05
Last updated: 2026-07-13
Interventions
Drug: Kisspeptin 112-121
Primary outcomes
- • Difference in mean luteinizing hormone (LH) amplitude between cases and controls (Day of study visit (one to two hours))
Sponsor
Stephanie B. Seminara, MD · other
With: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Contacts & investigators
ContactStudy Coordinator · contact · MGHKisspeptinResearch@partners.org · 617-643-2308
All locations (1)
Massachusetts General HospitalRecruiting
Boston, Massachusetts, United States