RecruitingRecruiting
TIVA Versus Balanced Anesthesia on Muscle Mass in CRC Surgery
NCT07237438 · Grigore T. Popa University of Medicine and Pharmacy
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Total Intravenous Anesthesia Versus Balanced Anesthesia on Loss of Muscle Mass After Colorectal Cancer Surgery
About this study
This study is aimed at clarifying changes in body composition during the perioperative period and identifying risk factors for skeletal muscle mass loss in patients with colorectal cancer. The investigators will asess the impact of the type of anaesthesia (total intravenous anaesthesia/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass, which will be evaluated using ultrasound, dynamometry and bioimpedance.
Eligibility criteria
Inclusion Criteria:
• adult patients diagnosed with colorectal cancer and scheduled for open colorectal surgery at the Regional Institute of Oncology, Iaşi, Romania
Exclusion Criteria:
* lack the capacity to consent
* extremity amputation
* paraplegia
* diseases affecting the muscles (such as stroke, lower-limb immobilization from a plaster, neurodegenerative diseases, peripheral neuropathy or muscle dystrophy)
* terminal cancer
Study design
Enrollment target: 40 participants
Allocation: randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2025-09-20
Estimated completion: 2026-06
Last updated: 2025-11-19
Interventions
Procedure: total intravenous anaesthesiaProcedure: sevoflurane anaesthesia
Primary outcomes
- • Ultrasonographic assessment of muscle mass (From enrollment to 5 days after surgery)
- • Muscle function assessment (From enrollment to 5 days after surgery)
- • Bioimpedance assessment of lean and fat tissue mass (From enrollment to 5 days after surgery)
Sponsor
Grigore T. Popa University of Medicine and Pharmacy · other
With: Regional Institute of Oncology, Iasi, Romania
Contacts & investigators
ContactIanis Siriopol · contact · ianis.siriopol@gmail.com · +40 746215 967
All locations (1)
Regional Institute of Oncology, Iaşi, RomaniaRecruiting
Iași, Romania