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Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women
NCT07265336 · Saint Thomas Hospital, Panama
In plain English
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Official title
Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients
About this study
The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.
This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.
The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.
Eligibility criteria
Inclusion Criteria:
* Gestational age: 24-40 weeks
* Cases: Diagnosis of severe preeclampsia
* Control: Normal blood pressure
Exclusion Criteria:
* Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure).
* Clinical conditions that could hinder the results (diarrhea, vomit)
* Recent use of bicarbonate
Study design
Enrollment target: 100 participants
Allocation: non_randomized
Masking: none
Age groups: child, adult, older_adult
Timeline
Starts: 2025-08-15
Estimated completion: 2026-01-31
Last updated: 2025-12-04
Interventions
Diagnostic Test: Arterial Blood gases
Primary outcomes
- • Value of excess base (Immediately before delivery)
- • Hypertensive crisis (From admission to day three (3) after delivery)
Sponsor
Saint Thomas Hospital, Panama · other
Contacts & investigators
ContactFrancisco Jordan, MD · contact · fcojordan19@gmail.com · +507 6983-0029
ContactAdriana Martinz, MD · contact · amartinzmd@gmail.com
InvestigatorOsvaldo Reyes, MD · study_chair, Saint Thomas Hospital, Panama
All locations (1)
Saint Thomas HospitalRecruiting
Panama City, Provincia de Panamá, Panama