The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

NCT07315997 · Brigham and Women's Hospital

Recruiting

In plain English

Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.

About this study

The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.

Eligibility criteria

Inclusion Criteria: * RA diagnosed by a rheumatologist * Age 40- 79 * ≥1 ASCVD risk factor including prediabetes, hypertension, BMI \>30, current or history of cigarette smoking Exclusion Criteria: * Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor * Patients with diabetes mellitus * Pregnancy

Study design

Enrollment target: 120 participants

Age groups: adult, older_adult

Timeline

Starts: 2024-09-04

Estimated completion: 2028-03-04

Last updated: 2026-01-05

Interventions

Diagnostic Test: high sensitivity cardiac troponin

Primary outcomes

• coronary artery calcium score (Cross-sectional, at baseline)

Sponsor

Brigham and Women's Hospital · other

With: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

All locations (1)

Brigham and Womens HospitalRecruiting

Boston, Massachusetts, United States

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