← Back to searchRecruitingRecruiting
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
NCT07321886 · Eli Lilly and Company
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes
About this study
The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase.
Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.
Eligibility criteria
Inclusion Criteria:
* Have Body Mass Index (BMI) at screening of the following:
* 30 kilogram per square meter (kg/m2) OR
* 27 kg/m2 with at least one of the following weight-related health conditions at screening:
* high blood pressure
* dyslipidemia
* obstructive sleep apnea, or
* heart disease
* Have a stable body weight (\<5% body weight change) for 90 days prior to screening.
* Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight
Exclusion Criteria:
* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes or type 2 diabetes
* Have had within 90 days prior to screening:
* heart attack
* stroke
* coronary artery revascularization
* unstable angina, or
* hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
* Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Study design
Enrollment target: 1980 participants
Allocation: randomized
Masking: double
Age groups: adult, older_adult
Timeline
Starts: 2026-02-06
Estimated completion: 2030-07
Last updated: 2026-04-17
Interventions
Drug: EloralintideDrug: Placebo
Primary outcomes
- • Percent Change from Baseline in Body Weight (Baseline, Week 64)
Sponsor
Eli Lilly and Company · industry
Contacts & investigators
ContactTrial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or · contact · LillyTrials@Lilly.com · 1-317-615-4559
ContactPhysicians interested in becoming principal investigators please contact · contact · clinical_inquiry_hub@lilly.com
InvestigatorCall 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · study_director, Eli Lilly and Company
All locations (173)
MFA Clinical ResearchRecruiting
Tuscaloosa, Alabama, United States
Headlands Research - ScottsdaleRecruiting
Scottsdale, Arizona, United States
Neighborhood Healthcare Institute of HealthRecruiting
Escondido, California, United States
Ark Clinical Research - Fountain ValleyRecruiting
Fountain Valley, California, United States
Desert Oasis Healthcare Medical GroupRecruiting
Palm Springs, California, United States
Peninsula Research AssociatesRecruiting
Rolling Hills Estates, California, United States
Care Access - SacramentoRecruiting
Sacramento, California, United States
Southern California Clinical ResearchRecruiting
Santa Ana, California, United States
University Clinical Investigators, Inc.Recruiting
Tustin, California, United States
Chase Medical Research, LLCRecruiting
Waterbury, Connecticut, United States
JEM Research InstituteRecruiting
Atlantis, Florida, United States
BioMed Research & Medical CenterRecruiting
Miami, Florida, United States
Adult Medicine of Lake County, Inc.Recruiting
Mt. Dora, Florida, United States
American Research Centers of FloridaRecruiting
Pembroke Pines, Florida, United States
AHF PensacolaRecruiting
Pensacola, Florida, United States
IMA Clinical Research St. PetersburgRecruiting
St. Petersburg, Florida, United States
Teak Research Consults - DunwoodyRecruiting
Dunwoody, Georgia, United States
Teak Research ConsultsRecruiting
Lawrenceville, Georgia, United States
Clinical Research AtlantaRecruiting
Stockbridge, Georgia, United States
East-West Medical Research InstituteRecruiting
Honolulu, Hawaii, United States
Iowa Diabetes and Endocrinology Research CenterRecruiting
West Des Moines, Iowa, United States
Cotton O'Neil Clinical Research CenterRecruiting
Topeka, Kansas, United States
Care Access - Lake Charles (Bayou Pines)Recruiting
Lake Charles, Louisiana, United States
MedStar Good Samaritan HospitalRecruiting
Baltimore, Maryland, United States
MedStar Health Research Institute (MedStar Physician Based Research Network)Recruiting
Hyattsville, Maryland, United States
Care Access - QuincyRecruiting
Quincy, Massachusetts, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionRecruiting
Troy, Michigan, United States
AMR ClinicalNot Yet Recruiting
Las Vegas, Nevada, United States
IMA Clinical Research WarrenRecruiting
Warren Township, New Jersey, United States
Albuquerque Clinical Trials, Inc.Recruiting
Albuquerque, New Mexico, United States
Rochester Clinical Research, LLCRecruiting
Rochester, New York, United States
Monroe Biomedical ResearchRecruiting
Monroe, North Carolina, United States
Preferred Primary Care PhysiciansRecruiting
Uniontown, Pennsylvania, United States
Tribe Clinical Research, LLCRecruiting
Greenville, South Carolina, United States
Accellacare - Mt PleasantRecruiting
Mt. Pleasant, South Carolina, United States
AMR ClinicalRecruiting
Nashville, Tennessee, United States
The University of Texas Health Science Center at HoustonRecruiting
Bellaire, Texas, United States
Velocity Clinical Research, DallasRecruiting
Dallas, Texas, United States
UT Southwestern Medical CenterRecruiting
Dallas, Texas, United States
IMA Clinical Research San AntonioRecruiting
San Antonio, Texas, United States
AMR ClinicalRecruiting
Norfolk, Virginia, United States
CONEXA Investigacion Clinica S.A.Not Yet Recruiting
Buenos Aires, Argentina
CIPRECNot Yet Recruiting
Buenos Aires, Argentina
Cicemo SrlNot Yet Recruiting
Buenos Aires, Argentina
Cardiología PalermoNot Yet Recruiting
Buenos Aires, Argentina
Glenny Corp. S.A.Not Yet Recruiting
Buenos Aires, Argentina
CARDIAMET Investigaciones MédicasNot Yet Recruiting
Buenos Aires, Argentina
Centro Médico ViamonteNot Yet Recruiting
Buenos Aires, Argentina
Fundación RespirarNot Yet Recruiting
Buenos Aires, Argentina
CEDICNot Yet Recruiting
CABA, Argentina
Instituto de Investigaciones Clínicas CórdobaNot Yet Recruiting
Córdoba, Argentina
CIPADI - Centro Integral de Prevencion y Atencion en DiabetesNot Yet Recruiting
Godoy Cruz, Argentina
INECO Neurociencias OroñoNot Yet Recruiting
Rosario, Argentina
Instituto Especialidades de la Salud RosarioNot Yet Recruiting
Rosario, Argentina
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención MedicaNot Yet Recruiting
Rosario, Argentina
Laboratorio de Hemostasia y TrombosisNot Yet Recruiting
Rosario, Argentina
Centro de Investigaciones Médicas TucumanNot Yet Recruiting
SAN M. de Tucuman, Argentina
Centro Modelo de CardiologíaNot Yet Recruiting
San Miguel de Tucumán, Argentina
Centro de Salud e Investigaciones MédicasNot Yet Recruiting
Santa Rosa, Argentina
Emeritus ResearchNot Yet Recruiting
Botany, Australia
Core Research GroupNot Yet Recruiting
Brisbane, Australia
Paratus Clinical Research CanberraNot Yet Recruiting
Bruce, Australia
Emeritus ResearchNot Yet Recruiting
Camberwell, Australia
Life Clinical ResearchNot Yet Recruiting
Ipswich, Australia
Paratus Clinical Research Central CoastNot Yet Recruiting
Kanwal, Australia
University of the Sunshine Coast (UniSC) Clinical Trials - MeadowbrookNot Yet Recruiting
Meadowbrook, Australia
Momentum SunshineNot Yet Recruiting
Melbourne, Australia
Paratus Clinical Research - MelbourneNot Yet Recruiting
Melbourne, Australia
AIM ResearchNot Yet Recruiting
Merewether, Australia
Fusion Clinical ResearchNot Yet Recruiting
Norwood, Australia
USC Clinical Trials Sunshine CoastNot Yet Recruiting
Sippy Downs, Australia
ANIMA ResearchRecruiting
Diepenbeek, Belgium
Jessa ZiekenhuisNot Yet Recruiting
Hasselt, Belgium
KormontRecruiting
Kluisbergen, Belgium
Gezondheidshuis De GloedRecruiting
Machelen, Belgium
Chronos Pesquisa ClínicaNot Yet Recruiting
Brasília, Brazil
Instituto de Pesquisa clinica de CampinasNot Yet Recruiting
Campinas, Brazil
Centro de Pesquisa Sao LucasNot Yet Recruiting
Campinas, Brazil
Private Practice - Dr.Miguel N. HissaNot Yet Recruiting
Fortaleza, Brazil
Centro de Pesquisa Clínica de Marília - CPCLIMNot Yet Recruiting
Marília, Brazil
Núcleo de Pesquisa Clínica do Rio Grande do SulNot Yet Recruiting
Porto Alegre, Brazil
IBPClin - Instituto Brasil de Pesquisa ClínicaNot Yet Recruiting
Rio de Janeiro, Brazil
Ruschel Medicina e Pesquisa ClínicaNot Yet Recruiting
Rio de Janeiro, Brazil
CPHosp Medicina, Ensino e Pesquisa (CPQuali)Not Yet Recruiting
São Paulo, Brazil
CPCLINNot Yet Recruiting
São Paulo, Brazil
CEPIC - Centro Paulista de Investigação ClínicaNot Yet Recruiting
São Paulo, Brazil
CEDOESNot Yet Recruiting
Vitória, Brazil
Integral Pesquisa e EnsinoNot Yet Recruiting
Votuporanga, Brazil
Aggarwal and Associates LimitedRecruiting
Brampton, Canada
Med Trust ResearchRecruiting
Courtice, Canada
Dawson Clinical Research Inc.Recruiting
Guelph, Canada
Winterberry Research Inc.Recruiting
Hamilton, Canada
The Wharton Medical Clinic Clinical Trials IncRecruiting
Hamilton, Canada
Alpha Recherche CliniqueRecruiting
Québec, Canada
ALPHA Recherche CliniqueRecruiting
Québec, Canada
Bluewater Clinical Research Group Inc.Recruiting
Sarnia, Canada
Diex Recherche Inc. Division Trois-RivieresRecruiting
Trois-Rivières, Canada
Luhe HospitalNot Yet Recruiting
Beijing, China
Beijing Pinggu District HospitalNot Yet Recruiting
Beijing, China
Sichuan Provincial People's HospitalNot Yet Recruiting
Chengdu, China
West China Hospital Sichuan UniversityNot Yet Recruiting
Chengdu, China
Zhujiang HospitalNot Yet Recruiting
Guangzhou, China
The Second People's Hospital of HefeiNot Yet Recruiting
Hefei, China
Jinan Central HospitalNot Yet Recruiting
Jinan, China
The First Affiliated Hospital of Henan University of Science &TechnologyNot Yet Recruiting
Luoyang Shi, China
Jiangxi Provincial People's HospitalNot Yet Recruiting
Nanchang, China
Nanjing First HospitalNot Yet Recruiting
Nanjing, China
Jiangsu Province Official HospitalNot Yet Recruiting
Nanjing, China
Zhongda Hospital Southeast UniversityNot Yet Recruiting
Nanjing, China
The Second Affiliated Hospital of Nanjing Medical UniversityNot Yet Recruiting
Nanjing, China
Shanghai Sixth People's HospitalNot Yet Recruiting
Shanghai, China
Zentrum fur klinische Forschung - KölnRecruiting
Cologne, Germany
Universitaetsklinikum Carl Gustav Carus DresdenNot Yet Recruiting
Dresden, Germany
StudyPoint DuisburgRecruiting
Duisburg, Germany
InnoDiab Forschung GmbhRecruiting
Essen, Germany
Medizentrum Essen BorbeckRecruiting
Essen, Germany
Diabetes Zentrum WilhelmsburgRecruiting
Hamburg, Germany
Diabeteszentrum Hamburg WestNot Yet Recruiting
Hamburg, Germany
AmBeNet GmbHRecruiting
Leipzig, Germany
Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. SchiwietzRecruiting
Lingen, Germany
BAG Drs. Med. Quist PartGNot Yet Recruiting
Mainz, Germany
CRS Clinical Research Services MannheimNot Yet Recruiting
Mannheim, Germany
RED-Institut GmbHRecruiting
Oldenburg, Germany
Praxis Sauter & Sauter & VorbachNot Yet Recruiting
Wangen, Germany
Endolife Speciality HospitalsNot Yet Recruiting
Guntur, India
Gauhati Medical College and HospitalNot Yet Recruiting
Guwahati, India
Care Hospitals Hyderabad- Banjara HillsNot Yet Recruiting
Hyderabad, India
Mandya Institute Of Medical SciencesNot Yet Recruiting
Mandya, India
Topiwala National Medical College & B. Y. L. Nair Charitable HospitalNot Yet Recruiting
Mumbai, India
Mysore Medical CollegeNot Yet Recruiting
Mysore, India
All India Institute of Medical Sciences (AIIMS) - NagpurNot Yet Recruiting
Nagpur, India
Supe Heart & Diabetes Hospital and Research CentreNot Yet Recruiting
Nashik, India
Lifepoint Multispeciality HospitalNot Yet Recruiting
Pune, India
Prabhu Diabetes Multi-Speciality CentreNot Yet Recruiting
Trichy, India
Adachi Kyosai HospitalRecruiting
Adachi-ku, Japan
Nihonbashi Sakura ClinicRecruiting
Chūōku, Japan
Medical Corporation Chiseikai Tokyo Center ClinicRecruiting
Chūōku, Japan
Tokyo-Eki Center-building ClinicRecruiting
Chūōku, Japan
Boocs Clinic FukuokaRecruiting
Fukuoka, Japan
Patient First Clinic Ginza-ShimbashiRecruiting
Minato, Japan
Kanno NaikaRecruiting
Mitaka, Japan
Medical Corporation Heishinkai OCROM ClinicRecruiting
Suita-shi, Japan
Higashi Shinjuku ClinicRecruiting
Tokyo, Japan
Zdrowie Osteo-MedicRecruiting
Bialystok, Poland
Legeartis - Poradnie SpecjalistyczneNot Yet Recruiting
Bialystok, Poland
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-METRecruiting
Krakow, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-AkcyjnaRecruiting
Lodz, Poland
Gabinety TERPANot Yet Recruiting
Lublin, Poland
EkamedRecruiting
Lublin, Poland
Centrum Zdrowia Metabolicznego Pawel BogdanskiRecruiting
Poznan, Poland
Pracownia Badań Klinicznych SalusRecruiting
Wroclaw, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1 SUMNot Yet Recruiting
Zabrze, Poland
Puerto Rico Health and Wellness InstituteRecruiting
Dorado, Puerto Rico
Wellness clinical Research Vega BajaRecruiting
Vega Baja, Puerto Rico
Gachon University Gil Medical CenterNot Yet Recruiting
Namdong-gu, South Korea
Konyang University HospitalNot Yet Recruiting
Seogu, South Korea
Seoul National University Bundang HospitalNot Yet Recruiting
Seongnam, South Korea
Seoul National University HospitalNot Yet Recruiting
Seoul, South Korea
Pusan National University Yangsan HospitalNot Yet Recruiting
Yangsan, South Korea
Chiayi Christian HospitalNot Yet Recruiting
Chiayi City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial HospitalNot Yet Recruiting
Kaohsiung City, Taiwan
Chang Gung Memorial Hospital at KaohsiungNot Yet Recruiting
Kaohsiung Niao Sung Dist, Taiwan
National Taiwan University HospitalNot Yet Recruiting
Taipei, Taiwan
Taipei Veterans General HospitalNot Yet Recruiting
Taipei, Taiwan
Layton Medical CentreNot Yet Recruiting
Blackpool, United Kingdom
Bradford on Avon Health CentreNot Yet Recruiting
Bradford-on-Avon, United Kingdom
Ashton Medical Group - Chapel HouseNot Yet Recruiting
Lancashire, United Kingdom
Royal Lancaster InfirmaryNot Yet Recruiting
Lancaster, United Kingdom
Altnagelvin Area HospitalNot Yet Recruiting
Londonderry, United Kingdom
Bodyline Clinic - OpenshawNot Yet Recruiting
Manchester, United Kingdom
Wansford Research LimitedNot Yet Recruiting
Peterborough, United Kingdom
Abbeywell SurgeryNot Yet Recruiting
Romsey, United Kingdom
Rame Group PracticeNot Yet Recruiting
Torpoint, United Kingdom