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A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
NCT07392190 · Eli Lilly and Company
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Persistent Obesity or Overweight Treated With a Weekly Incretin, With and Without Type 2 Diabetes
About this study
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy.
Participation in the study will last about 80 weeks.
Eligibility criteria
Inclusion Criteria:
* Are on stable incretin therapy at screening
* With persistent obesity or overweight defined as:
* ≥30 kg/m2 OR
* ≥27 kg/m2 with at least one existing obesity related complication at screening:
* hypertension
* dyslipidemia
* obstructive sleep apnea
* cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or
* type 2 diabetes
* Have a stable body weight (\<5% body weight change) at screening
Exclusion Criteria:
* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes
* Have taken any of the following antihyperglycemic medications within 90 days before screening:
* dipeptidyl peptidase-4 (DPP-4) inhibitors
* amylin analogs
* insulin
* Have had within 90 days prior to screening:
* heart attack
* stroke
* coronary artery revascularization
* unstable angina, or
* hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
Study design
Enrollment target: 900 participants
Allocation: randomized
Masking: double
Age groups: adult, older_adult
Timeline
Starts: 2026-02-10
Estimated completion: 2028-07
Last updated: 2026-04-17
Interventions
Drug: EloralintideDrug: Placebo
Primary outcomes
- • Percent Change from Baseline in Body Weight (Baseline, Week 64)
Sponsor
Eli Lilly and Company · industry
Contacts & investigators
ContactTrial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · contact · LillyTrials@Lilly.com · 317-615-4559
ContactPhysicians interested in becoming principal investigators please contact · contact · clinical_inquiry_hub@lilly.com
InvestigatorCall 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · study_director, Eli Lilly and Company
All locations (178)
Birmingham Clinical ResearchRecruiting
Birmingham, Alabama, United States
RIO Clinical Trials - PhoenixRecruiting
Phoenix, Arizona, United States
Headlands Research - ScottsdaleRecruiting
Scottsdale, Arizona, United States
Novak Clinical Research - Tucson - North La Cholla BoulevardRecruiting
Tucson, Arizona, United States
Irvine Clinical ResearchRecruiting
Irvine, California, United States
Scripps Whittier Diabetes InstituteNot Yet Recruiting
La Jolla, California, United States
Peninsula Research AssociatesRecruiting
Rolling Hills Estates, California, United States
Care Access - SacramentoRecruiting
Sacramento, California, United States
Artemis Institute for Clinical ResearchRecruiting
San Diego, California, United States
Southern California Clinical ResearchRecruiting
Santa Ana, California, United States
University Clinical Investigators, Inc.Recruiting
Tustin, California, United States
New England Research Associates, LLCRecruiting
Bridgeport, Connecticut, United States
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New Haven, Connecticut, United States
Chase Medical Research, LLCRecruiting
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JEM Research InstituteRecruiting
Atlantis, Florida, United States
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Doral, Florida, United States
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Fleming Island, Florida, United States
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New Horizon Research CenterRecruiting
Miami, Florida, United States
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Saint Augustine, Florida, United States
Metabolic Research Institute, Inc.Recruiting
West Palm Beach, Florida, United States
Teak Research Consults - DunwoodyRecruiting
Dunwoody, Georgia, United States
Center for Advanced Research & EducationRecruiting
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Family First Medical CenterRecruiting
Idaho Falls, Idaho, United States
Great Lakes Clinical Trials - RavenswoodRecruiting
Chicago, Illinois, United States
Iowa Diabetes and Endocrinology Research CenterRecruiting
West Des Moines, Iowa, United States
Cotton O'Neil Diabetes & EndocrinologyRecruiting
Topeka, Kansas, United States
AMR ClinicalRecruiting
Lexington, Kentucky, United States
IMA Clinical Research Monroe - ArmandRecruiting
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Centennial Medical GroupRecruiting
Columbia, Maryland, United States
Brigham and Women's Hospital Diabetes ProgramNot Yet Recruiting
Boston, Massachusetts, United States
Great Lakes Research InstituteRecruiting
Southfield, Michigan, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionRecruiting
Troy, Michigan, United States
Clinical Research ProfessionalsRecruiting
Chesterfield, Missouri, United States
NYU Langone HealthNot Yet Recruiting
New York, New York, United States
Weill Cornell Medical CollegeNot Yet Recruiting
New York, New York, United States
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New York, New York, United States
University of North Carolina Medical CenterRecruiting
Chapel Hill, North Carolina, United States
Medication ManagementRecruiting
Greensboro, North Carolina, United States
Carteret Medical GroupRecruiting
Morehead City, North Carolina, United States
Accellacare - Wilmington - 1917 Tradd CourtRecruiting
Wilmington, North Carolina, United States
Care Access - LimaRecruiting
Lima, Ohio, United States
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)Recruiting
Pittsburgh, Pennsylvania, United States
UT Southwestern Medical CenterRecruiting
Dallas, Texas, United States
Juno ResearchRecruiting
Houston, Texas, United States
Synergy Groups Medical LLC - Missouri CityRecruiting
Missouri City, Texas, United States
IMA Clinical Research San AntonioRecruiting
San Antonio, Texas, United States
Endeavor Clinical TrialsRecruiting
San Antonio, Texas, United States
Consano Clinical Research, LLCRecruiting
Shavano Park, Texas, United States
Texas Valley Clinical ResearchRecruiting
Weslaco, Texas, United States
Medrasa Clinical ResearchRecruiting
Wylie, Texas, United States
Emeritus ResearchNot Yet Recruiting
Botany, Australia
Box Hill HospitalNot Yet Recruiting
Box Hill, Australia
Royal Brisbane and Women's HospitalNot Yet Recruiting
Brisbane, Australia
Emeritus ResearchNot Yet Recruiting
Camberwell, Australia
Barwon HealthNot Yet Recruiting
Geelong, Australia
Austin Health - Repatriation HospitalNot Yet Recruiting
Heidelberg West, Australia
AIM ResearchNot Yet Recruiting
Merewether, Australia
Southern Adelaide Diabetes & Endocrine ServicesNot Yet Recruiting
Oaklands Park, Australia
Royal North Shore HospitalNot Yet Recruiting
St Leonards, Australia
Innovate Clinical ResearchNot Yet Recruiting
Waitara, Australia
Imelda General HospitalNot Yet Recruiting
Bonheiden, Belgium
Université Libre de Bruxelles - Hôpital ErasmeNot Yet Recruiting
Brussels, Belgium
Ziekenhuis Oost-Limburg, Campus St.-JanNot Yet Recruiting
Genk, Belgium
Jan Yperman ZiekenhuisNot Yet Recruiting
Ieper, Belgium
AZ Groeninge Campus KennedylaanNot Yet Recruiting
Kortrijk, Belgium
UZ LeuvenNot Yet Recruiting
Leuven, Belgium
AZ Sint-MaartenNot Yet Recruiting
Mechelen, Belgium
MeclinasNot Yet Recruiting
Mechelen, Belgium
Az Damiaan vzwNot Yet Recruiting
Ostend, Belgium
Quanta Diagnóstico e TerapiaNot Yet Recruiting
Curitiba, Brazil
Centro de Diabetes CuritibaNot Yet Recruiting
Curitiba, Brazil
Private Practice - Dr.Miguel N. HissaNot Yet Recruiting
Fortaleza, Brazil
CPCLINNot Yet Recruiting
São Paulo, Brazil
Hospital 9 De JulhoNot Yet Recruiting
São Paulo, Brazil
CEDOESNot Yet Recruiting
Vitória, Brazil
Integral Pesquisa e EnsinoNot Yet Recruiting
Votuporanga, Brazil
Luhe HospitalNot Yet Recruiting
Beijing, China
The First Hospital of Jilin UniversityNot Yet Recruiting
Changchun, China
The Second Hospital of Jilin UniversityNot Yet Recruiting
Changchun, China
The Second Xiangya Hospital of Central South UniversityNot Yet Recruiting
Changsha, China
Sichuan Provincial People's HospitalNot Yet Recruiting
Chengdu, China
West China Hospital Sichuan UniversityNot Yet Recruiting
Chengdu, China
2nd Affiliated Hospital Chongqing Medical UniversiNot Yet Recruiting
Chongqing, China
Zhujiang HospitalNot Yet Recruiting
Guangzhou, China
The Affiliated Hospital of Guizhou Medical UniversityNot Yet Recruiting
Guiyang, China
The Second People's Hospital of HefeiNot Yet Recruiting
Hefei, China
Huzhou Central HospitalNot Yet Recruiting
Huzhou, China
The First Affiliated Hospital of Henan University of Science &TechnologyNot Yet Recruiting
Luoyang Shi, China
Affiliated Hospital of Luzhou Medical CollegeNot Yet Recruiting
Luzhou, China
Jiangxi Provincial People's HospitalNot Yet Recruiting
Nanchang, China
Nanjing First HospitalNot Yet Recruiting
Nanjing, China
Zhongda Hospital Southeast UniversityNot Yet Recruiting
Nanjing, China
The Second Affiliated Hospital of Nanjing Medical UniversityNot Yet Recruiting
Nanjing, China
Ningbo First HospitalNot Yet Recruiting
Ningbo, China
Zhongshan Hospital,Fudan UniversityNot Yet Recruiting
Shanghai, China
The Central Hospital of WuhanNot Yet Recruiting
Wuhan, China
Diahaza s.r.o.Not Yet Recruiting
Holešov, Czechia
MUDr. Michala Pelikanova s.r.o.Not Yet Recruiting
Prague, Czechia
Milan Kvapil s.r.o., Diabetologicka ambulanceNot Yet Recruiting
Prague, Czechia
ResTrial s.r.o.Not Yet Recruiting
Prague, Czechia
Motilal Nehru Medical College HospitalNot Yet Recruiting
Allahābād, India
Life Care Hospital and Research CentreNot Yet Recruiting
Bangalore, India
Madras Diabetes Research FoundationNot Yet Recruiting
Chennai, India
Nizam's Institute of Medical SciencesNot Yet Recruiting
Hyderabad, India
Eternal Heart Care Center and Research InstituteNot Yet Recruiting
Jaipur, India
Atmaram Child CareNot Yet Recruiting
Kanpur, India
Shree Mahalaxmi DIATONE InstituteNot Yet Recruiting
Kolhāpur, India
BSES MG HospitalNot Yet Recruiting
Mumbai, India
Mysore Medical CollegeNot Yet Recruiting
Mysore, India
All India Institute of Medical Sciences (AIIMS) - NagpurNot Yet Recruiting
Nagpur, India
Supe Heart & Diabetes Hospital and Research CentreNot Yet Recruiting
Nashik, India
Nirmal Hospital Pvt Ltd.Not Yet Recruiting
Surat, India
Emek Medical CenterNot Yet Recruiting
Afula, Israel
Clalit Health Services - AtlitNot Yet Recruiting
Atlit, Israel
Soroka Medical CenterNot Yet Recruiting
Beersheba, Israel
Hillel Yaffe Medical CenterNot Yet Recruiting
Hadera, Israel
Rambam Health Care CampusNot Yet Recruiting
Haifa, Israel
Edith Wolfson Medical CenterNot Yet Recruiting
Holon, Israel
Hadassah Medical CenterNot Yet Recruiting
Jerusalem, Israel
Meir Medical CenterNot Yet Recruiting
Kfar Saba, Israel
Maccabi health care services - Qiryat MotzkinNot Yet Recruiting
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Laniado HospitalNot Yet Recruiting
Netanya, Israel
Rabin Medical Center - Hasharon CampusNot Yet Recruiting
Petah Tikva, Israel
Rabin Medical CenterNot Yet Recruiting
Petah Tikva, Israel
Sheba Medical CenterNot Yet Recruiting
Ramat Gan, Israel
Kaplan Medical CenterNot Yet Recruiting
Rehovot, Israel
Clalit Health Services - Sakhnin Community ClinicNot Yet Recruiting
Sakhnin, Israel
Diabetes Medical CenterNot Yet Recruiting
Tel Aviv, Israel
Sourasky Medical CenterNot Yet Recruiting
Tel Aviv, Israel
The Institute of Medical Science, Asahi Life FoundationNot Yet Recruiting
Chūōku, Japan
Rinku General Medical CenterNot Yet Recruiting
Izumisano, Japan
Kanto Rosai HospitalNot Yet Recruiting
Kawasaki, Japan
Kimitsu Chuo HospitalNot Yet Recruiting
Kisarazu, Japan
Kure Medical CenterNot Yet Recruiting
Kure, Japan
Takeda General Hospital - KyotoNot Yet Recruiting
Kyoto, Japan
Mikannohana Clinic, Diabetes, Endocrinology and MetabolismNot Yet Recruiting
Matsuyama, Japan
Kansai Electric Power HospitalNot Yet Recruiting
Osaka, Japan
Manda Memorial HospitalNot Yet Recruiting
Sapporo, Japan
Shimonoseki Medical CenterNot Yet Recruiting
Shimonoseki, Japan
Japanese Red Cross Society - Wakayama Medical CenterNot Yet Recruiting
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Medical Center MetasNot Yet Recruiting
Chihuahua City, Mexico
Private Practice - Dr. Arechavaleta Granell Maria del RosarioNot Yet Recruiting
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Invecordis S.C.Not Yet Recruiting
Huixquilucan, Mexico
Centro de Investigacion en Artritis y Osteoporosis SCNot Yet Recruiting
Mexicali, Mexico
CEINV SaludNot Yet Recruiting
Monterrey, Mexico
Clínica García Flores SCNot Yet Recruiting
Monterrey, Mexico
Advanced Clinical Research, LLCNot Yet Recruiting
Bayamón, Puerto Rico
Isis Clinical Research CenterNot Yet Recruiting
Guaynabo, Puerto Rico
Mariodiab ClinicNot Yet Recruiting
Brasov, Romania
C.M.D.T.A. NeomedNot Yet Recruiting
Brasov, Romania
Geea Medical Easy DietNot Yet Recruiting
Bucharest, Romania
Centrul Medical NutriLifeNot Yet Recruiting
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Gama DiamedNot Yet Recruiting
Mangalia, Romania
DiabdanaNot Yet Recruiting
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Clinica KorallNot Yet Recruiting
Satu Mare, Romania
Rinart Diab SRLNot Yet Recruiting
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SC Dentosim Queen SRL - Centrul Medical DiamedNot Yet Recruiting
Târgu Mureş, Romania
Cabinet Medical Dr.GeruNot Yet Recruiting
Timișoara, Romania
Hospital San Rafael - La CoruñaNot Yet Recruiting
A Coruña, Spain
Centro Periférico de Especialidades Bola AzulNot Yet Recruiting
Almería, Spain
Hospital Universitari Vall d'HebronNot Yet Recruiting
Barcelona, Spain
Instituto Gallego de Cirugía OcularNot Yet Recruiting
Ferrol, Spain
Clínica JuanedaNot Yet Recruiting
Palma de Mallorca, Spain
Hospital Universitario Quironsalud MadridNot Yet Recruiting
Pozuelo de Alarcón, Spain
Hospital Universitario Marqués de ValdecillaNot Yet Recruiting
Santander, Spain
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)Not Yet Recruiting
Seville, Spain
Hospital Quiron Infanta LuisaNot Yet Recruiting
Seville, Spain
Vithas Hospital SevillaNot Yet Recruiting
Seville, Spain
Chiayi Christian HospitalNot Yet Recruiting
Chiayi City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial HospitalNot Yet Recruiting
Kaohsiung City, Taiwan
Chang Gung Memorial Hospital at KaohsiungNot Yet Recruiting
Kaohsiung Niao Sung Dist, Taiwan
China Medical University HospitalNot Yet Recruiting
Taichung, Taiwan
National Cheng Kung University HospitalNot Yet Recruiting
Tainan, Taiwan
National Taiwan University HospitalNot Yet Recruiting
Taipei, Taiwan
Taipei Medical University HospitalNot Yet Recruiting
Taipei, Taiwan
Taipei Veterans General HospitalNot Yet Recruiting
Taipei, Taiwan
Chang Gung Medical Foundation-Linkou BranchNot Yet Recruiting
Taoyuan District, Taiwan