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Neurophysiology of Reward Signaling in Parkinson's Disease
NCT07409207 · Vanderbilt University Medical Center
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Eligibility criteria
Inclusion Criteria:
* Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
* Planned clinical electrode trajectory that contacts caudate
* Age greater than or equal to 40
* Diagnosis of Parkinson's disease or other movement disorder
* Able to participate in intraoperative testing
* English speaking
Exclusion Criteria:
* Age less than 40
* Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
Study design
Enrollment target: 75 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2024-09-01
Estimated completion: 2029-09-30
Last updated: 2026-02-13
Interventions
Other: Neurophysiology recordingsOther: Neural stimulation
Primary outcomes
- • Changes in caudate DLPFC beta coherence (Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours)
- • Changes in gambling task performance with neural stimulation (Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours)
Sponsor
Vanderbilt University Medical Center · other
Contacts & investigators
ContactIsabel Long, BS · contact · isabel.long@vumc.org · 615-421-3046
ContactSarah Bick, MD · contact · sarah.bick@vumc.org · 615-343-9822
InvestigatorSarah Bick · principal_investigator, Vanderbilt University Medical Center
All locations (1)
Vanderbilt University Medical CenterRecruiting
Nashville, Tennessee, United States