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Motor and Cognitive Exercise in Parkinson's Disease.

NCT07465107 · University Hospital Bispebjerg and Frederiksberg
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Official title
Motor and Cognitive Exercise in Parkinson's Disease. A Feasibility Randomized Clinical Trial
About this study
Intervention: The exercise program will consist of gait and balance training, lower body strength training and dual task training while treadmill walking. The program will include an individualized and progressive exercise program 3 times x 1 hour a week for 12 weeks with the following exercise modalities: 1. Treadmill training for gait and balance training combined with dual task motor cognitive training. 2. Progressive gait and motor-cognitive balance exercises 3. Progressive resistance training including leg press. The program will be conducted under supervision by a physiotherapist or an exercise physiologist. Usual treatment is permitted during the trial, both pharmacological and non-pharmacological. The treatment is preferably stable during the intervention and follow-up, but necessary changes will be registered. All participants will be examined at baseline, after 12 weeks and again 6 and 12 months after baseline.
Eligibility criteria
Inclusion Criteria: * Diagnosis of PD according to MDS-PD criteria * Aged ≥ 18 years * Informed consent * PD symptoms ≥ 4 years * Independent gait Exclusion Criteria: * Diagnosis of PD Dementia according to the MDS-PD Dementia criteria
Study design
Enrollment target: 48 participants
Allocation: randomized
Masking: single
Age groups: adult, older_adult
Timeline
Starts: 2025-03-26
Estimated completion: 2027-02-14
Last updated: 2026-03-11
Interventions
Other: Motor-cognitive exerciseOther: Usual Care
Primary outcomes
  • Feasibility: Intervention adherence (From allocation to the end of 12 weeks of intervention (T2))
  • Exploratory composite clinical outcome: Significant fall, all-cause hospitalization and all-cause mortality (From enrollment to 1-year follow-up (T4))
Sponsor
Annemette Lokkegaard · other
With: Copenhagen Trial Unit, Center for Clinical Intervention Research
Contacts & investigators
ContactAnnemette Løkkegaard, MD, PhD · contact · annemette.loekkegaard@regionh.dk · +45 38 63 52 48
ContactLøkkegaard · contact
All locations (1)
Department of Neurology, Bispebjerg and Frederiksberg HospitalRecruiting
Copenhagen NV, Denmark