RecruitingRecruiting
Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease
NCT07535008 · Fred Hutchinson Cancer Center
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
OUTLINE:
Patients who have not undergone dental cleaning within 3 months preceding the baseline visit undergo dental cleaning at baseline (before the initiation of transplant conditioning) according to standard of care. All patients undergo simplified dental cleaning on day +28 following HCT.
After completion of study intervention, patients are followed up on days +84 and +180 and at 1 year.
Eligibility criteria
Inclusion Criteria:
* Age ≥ 18 years old
* T-replete allogeneic hematopoietic cell transplantation for any indication. History of prior transplantation is allowed. Any conditioning regimen is allowed
* One of the following HCT donor types:
* 9/10 or 10/10 human leukocyte antigen (HLA)-matched unrelated donor
* Cord blood
* Willing to have an in-person 1-year long-term follow-up (LTFU) visit including an oral medicine at Fred Hutch (FH)
* Ability to understand and sign a written informed consent document (or legal representative)
Exclusion Criteria:
* Edentulous state
* Bone marrow as graft source
* Use of post-transplantation cyclophosphamide (PTCy) or ruxolitinib as GVHD prophylaxis
* Use of anti-thymocyte globulin (ATG) in conditioning
Study design
Enrollment target: 45 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2026-06-15
Estimated completion: 2029-04-30
Last updated: 2026-05-26
Interventions
Procedure: Dental CleaningProcedure: Dental Plaque sampling
Primary outcomes
- • Probability of moderate-to-severe chronic graft versus host disease (At 1-year post-transplant)
Sponsor
Fred Hutchinson Cancer Center · other
Contacts & investigators
ContactArmin Rashidi, MD, PhD · contact · arashidi@fredhutch.org · 206-667-2506
InvestigatorArmin Rashidi, MD, PhD · principal_investigator, Fred Hutch/University of Washington Cancer Consortium
All locations (1)
Fred Hutch/University of Washington Cancer ConsortiumRecruiting
Seattle, Washington, United States