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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
NCT07589608 · Eli Lilly and Company
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
A Phase 2b, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes
About this study
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.
Eligibility criteria
Inclusion Criteria:
* See Master Protocol CWMM (NCT06143956) for inclusion criteria
Exclusion Criteria:
In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):
* Have type 1 diabetes or type 2 diabetes
* Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
* Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
* Have a history of acute or chronic pancreatitis
* All concomitant medications should be at a stable dose for at least 3 months prior to screening
Study design
Enrollment target: 400 participants
Allocation: randomized
Masking: double
Age groups: adult, older_adult
Timeline
Starts: 2026-05-15
Estimated completion: 2028-02
Last updated: 2026-06-24
Interventions
Drug: MacupatideDrug: EloralintideDrug: Placebo
Primary outcomes
- • Percent Change from Baseline in Body Weight (Baseline, Week 36)
Sponsor
Eli Lilly and Company · industry
Contacts & investigators
ContactTrial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · contact · LillyTrials@Lilly.com · 317-615-4559
ContactPhysicians interested in becoming principal investigators please contact · contact · clinical_inquiry_hub@lilly.com
InvestigatorCall 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · study_director, Eli Lilly and Company
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