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Recruiting

Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts

NCT07767227 · Translational Genomics Research Institute
In plain English

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Official title
Pilot Proof of Concept Study of miRNA and Protein Signatures in Exosomes From Blood and Cystic Fluid in Patients Undergoing Surgery for Worrisome Pancreatic Cysts
About this study
The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection. The blood and fluid samples will be analyzed for research into DNA, RNA, and proteins.
Eligibility criteria
Inclusion Criteria: * Voluntarily agree to participate by giving written informed consent prior to any study-specific procedures. * Subject at least 18 years of age and able to provide consent. Subject is willing and able to comply with requirements of the protocol. * Radiologically documented cyst of the pancreas for which surgical removal is clinically indicated. * Patient will be undergoing a surgical resection of their pancreatic cystic neoplasm. Exclusion Criteria: * Patient who is pregnant at the time of study enrollment and sample collection. * Patient will not be undergoing clinically indicated surgery for a pancreatic cystic neoplasm. * Patient is unwilling or unable to provide informed consent or comply with study procedures.
Study design
Enrollment target: 30 participants
Age groups: adult, older_adult
Timeline
Starts: 2025-02-03
Estimated completion: 2028-03
Last updated: 2026-08-17
Primary outcomes
  • Characterize the miRNA and protein signatures in exosomes derived from blood and cyst fluids in patients with worrisome cystic pancreatic tumors (At enrollment)
Sponsor
Translational Genomics Research Institute · other
With: Hoag Memorial Hospital Presbyterian, City of Hope National Medical Center, Piedmont Healthcare
Contacts & investigators
ContactMichael Demeure, MD · contact · clinicalresearch@hoag.org · 949-764-4577
InvestigatorMichael Demeure, MD · principal_investigator, Hoag Family Cancer Institute
All locations (2)
Hoag Family Cancer InstituteRecruiting
Newport Beach, California, United States
Piedmont HealthCareRecruiting
Atlanta, Georgia, United States
Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts · TrialPath