RecruitingRecruiting
Biofluid Research on Age-Related or Inherited Neurodegeneration
NCT07798700 · University of Pennsylvania
In plain English
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Official title
Biofluid Research on Age-Related or Inherited Neurodegeneration (BRAIN)
About this study
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with age-related neurodegenerative conditions, or their family members who may or may not be at risk for similar conditions. This study will continue to further expand research into the molecular and genetic basis of these diseases and their risk factors.
Eligibility criteria
Inclusion Criteria:
1. People with a clinical diagnosis of a neurodegenerative disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), primary progressive aphasia (PPA), limbic-predominant age-related TDP-43 encephalopathy (LATE), corticobasal syndrome (CBS), posterior cortical atrophy (PCA), primary lateral sclerosis (PLS), primary muscular atrophy (PMA), or individuals with a suspected neurodegenerative dementia and/or movement disorder of unknown etiology will be considered for enrollment
2. Family Members of individuals who meet the criteria of group 1, who are people who may or may not be at risk for a similar neurodegenerative disease, who may or may not be symptomatic, and who may or may not have known or unknown genetic risk.
3. People with no known neurological disease who will provide control data.
Exclusion Criteria:
1. Anyone who is under the age of 18.
2. Anyone with a condition or in a situation which, in the investigator's opinion, could confound the study findings or may interfere significantly with a person's participation, including but not limited to neurological, psychological, and other medical conditions (such as cardiac, neurosurgical, infectious conditions).
Study design
Enrollment target: 1000 participants
Age groups: adult, older_adult
Timeline
Starts: 2025-12-12
Estimated completion: 2070-01-01
Last updated: 2026-09-01
Primary outcomes
- • To contribute to and continue to sustain a repository biological samples and data from individuals with age-related neurodegenerative conditions. (This is a natural history study-participants are followed from date of enrollment until death, withdraw, or funding is no longer available, or until 600 months have passed.)
Sponsor
University of Pennsylvania · other
With: University of Pennsylvania Institute on Aging, National Institute on Aging (NIA), National Institute of Neurological Disorders and Stroke (NINDS)
Contacts & investigators
ContactCara Joyce, MPH · contact · cara.joyce@pennmedicine.upenn.edu · 267-271-0740
ContactEmily Xie · contact · emily.xie@pennmedicine.upenn.edu · 16109553114
InvestigatorCorey McMillan, PhD · principal_investigator, University of Pennsylvania
All locations (1)
University of PennsylvaniaRecruiting
Philadelphia, Pennsylvania, United States