RecruitingRecruiting
Lung Cancer Biomarkers and Screening
NCT00301119 · NYU Langone Health
In plain English
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Official title
NYU Lung Cancer Biomarker Center
About this study
OBJECTIVES:
* Identify and validate biomarkers for the early detection of lung cancer in individuals at low- or high-risk for smoking-related cancers.
* Identify preneoplastic cellular changes and lesions in these patients.
OUTLINE: Participants are stratified according to lung cancer risk status (with or without increased risk).
Group 1 (screening cohort): Participants complete a questionnaire and undergo pulmonary function testing, multidetector chest CT scan, sputum induction, and phlebotomy.
Group 2 (rule-out lung cancer): Participants complete the same questionnaire and undergo the same tests and scans as in group 1. Some participants may undergo fiberoptic bronchoscopy based upon CT scan results with transbronchial or endobronchial biopsies. Some participants may undergo lung resection. Tissue samples are collected from surgery or biopsy.
PROJECTED ACCRUAL: A total of participants will be accrued for this study.
Eligibility criteria
DISEASE CHARACTERISTICS:
* Screening Cohort
* At high- or low-risk for lung cancer
* Smoking history ≥ 20 pack years\*
* With or without workplace exposure to asbestos
* NOTE: \* Participants with \< 20 pack years of smoking are eligible if 50 years of age or older
* Rule-Out Lung cancer group
* Referred for evaluation of suspicious nodules with 1 of the following diagnoses:
* Lung cancer
* Nonmalignant nodules (control group)
PATIENT CHARACTERISTICS:
* Not pregnant
* No prior malignancy except nonmelanoma skin cancer
PRIOR CONCURRENT THERAPY:
* Not specified
Study design
Enrollment target: 3606 participants
Age groups: adult, older_adult
Timeline
Starts: 2000-05
Estimated completion: 2030-05
Last updated: 2026-05-08
Primary outcomes
- • Lung cancer diagnosis as measured by CT scan findings and pathology findings annually (07/01/2015)
Sponsor
NYU Langone Health · other
Contacts & investigators
ContactJames J. Tsay, MD, MSc · contact · Jun-Chieh.Tsay@nyulangone.org · 212-598-6351
ContactRosemary M Schluger · contact · rosemary.schluger@nyulangone.org · 212-263-0255
InvestigatorJames J. Tsay, MD, MSc · principal_investigator, NYU Langone Health
All locations (1)
NYU Cancer Institute at New York University Medical CenterRecruiting
New York, New York, United States