RecruitingRecruiting
Lung Cancer Screening in High-risk Black Individuals
NCT05898594 · Massachusetts General Hospital
In plain English
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Official title
Evaluating the Feasibility of Lung Cancer Screening in High-risk Black Individuals
About this study
The goal of this single-arm pilot research study is to evaluate the feasibility and acceptability of low-dose computed tomography (LDCT) screening for lung cancer among U.S. Black individuals with a history of smoking.
LDCT screening is currently the only recommended way to screen for lung cancer among high-risk individuals. However, many Black individuals at high-risk for lunch cancer are currently ineligible for lung cancer screening.
Study procedures include screening for eligibility, completion of questionnaires, and a LDCT screening test.
Participation in this study is expected to last up to 3 months.
It is expected about 900 people will participate in this study.
Eligibility criteria
Inclusion Criteria:
* Self-identified Black individual.
* Have a self-reported history of smoking. No restriction will be placed on the number of smoking pack years participants must have nor the number of years former smokers must have quit smoking.
* Aged 50-80 years.
Exclusion Criteria:
* Individuals with a history of lung cancer.
* Individuals with symptoms suggestive of lung cancer. We will evaluate whether individuals have symptoms suggestive of lung cancer by administering an online screening questionnaire, which will ask whether they have experienced shortness of breath, whether they become easily winded, and whether they have had a chronic cough within the last 12 weeks that has not improved. Individuals who select that they have any one of these symptoms will be advised to follow up with their primary doctor and will not be eligible to participate in the study.
* Individuals with pneumonia or acute respiratory infection within 12 weeks prior to enrollment that was treated with antibiotics.
Study design
Enrollment target: 900 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2023-09-06
Estimated completion: 2028-06-30
Last updated: 2026-02-23
Interventions
Procedure: Low-dose Computed Tomography
Primary outcomes
- • Proportion of Enrolled Participants (At enrollment)
- • Proportion of Participants with Positive Low-dose Computed Tomography Test (At 3 months)
- • Proportion of Participants Diagnosed with Invasive Lung Cancer (At 6 months)
Sponsor
Massachusetts General Hospital · other
With: Agency for Healthcare Research and Quality (AHRQ)
Contacts & investigators
ContactChi Fu Jeffrey Yang, MD · contact · cjyang@mgh.harvard.edu · 617-724-1681
InvestigatorChi Fu Jeffrey Yang, MD · principal_investigator, Massachusetts General Hospital
All locations (2)
University of ChicagoRecruiting
Chicago, Illinois, United States
Massachusetts General Hospital Cancer CenterRecruiting
Boston, Massachusetts, United States