RecruitingRecruiting
Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers
NCT06626243 · Scientific Institute San Raffaele
In plain English
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Official title
An International Multicenter Retrospective Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy
About this study
The use of neoadjuvant chemo-immunotherapy for the treatment of non-small cell lung cancer (NSCLC) is increasing. However, there is limited research comparing the feasibility and oncologic efficacy of robot-assisted thoracoscopic surgery (RATS), video-assisted thoracoscopic surgery (VATS), and open lung resection, in patients already treated with neoadjuvant chemo-immunotherapy. This study aims to evaluate the benefits of RATS compared to VATS and open surgery in terms of short-term outcomes for patients with NSCLC undergoing neoadjuvant chemo-immunotherapy.
All adult patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection from 01-01-2016 to 31-03-2024 by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy will be included.
Patients are divided into three groups: robotic lung resection; video-assisted thoracoscopic (VATS) lung resection; open lung resection.
Eligibility criteria
Inclusion Criteria:
* Diagnosis of clinical or pathological stage IIB (T1-2, hilar N1, M0) and III (any T, N1-2, M0) NSCLC surgically treated with robotic, VATS and open approach with radical intent from 1st of January 2016 to 31st of March 2024
* Received neoadjuvant chemo-immunotherapy or immunotherapy alone
* Age \>= 18 years old at the moment of surgery
Exclusion Criteria:
* Age \<18 years old at the moment of surgery
Study design
Enrollment target: 140 participants
Age groups: adult, older_adult
Timeline
Starts: 2024-09-30
Estimated completion: 2025-10-15
Last updated: 2024-11-29
Primary outcomes
- • The perioperative complication of video-assisted thoracoscopic surgery (VATS) approach (30-90 days after surgery)
- • The perioperative complications of robotic approach (from the surgery at 30-90 days after)
- • The perioperative complications of the open approach (30-90 days after surgery)
Sponsor
Scientific Institute San Raffaele · other
With: Memorial Sloan Kettering Cancer Center, Istituto Clinico Humanitas, Regina Elena Cancer Institute, Baptist Health South Florida, West Virginia University
Contacts & investigators
ContactPierluigi Novellis, Medical Doctor · contact · novellis.pierluigi@hsr.it · 0226437202
All locations (6)
Baptist Health South FloridaRecruiting
Miami, Florida, United States
Memorial Sloan Kettering Cancer CenterRecruiting
New York, New York, United States
West Virginia UniversityRecruiting
Morgantown, West Virginia, United States
Istituto Clinico HumanitasRecruiting
Rozzano, Milan, Italy
Scientific Institute Ospedale San RaffaeleRecruiting
Milan, Italy
Regina Elena National Cancer InstituteRecruiting
Rome, Italy