TrialPath
Anxiety · Boston

Anxiety clinical trials in Boston

20 recruiting anxiety disorder studies within range of Boston. Click any trial for full eligibility criteria and contact info.

Foundational Programs to Combat Clinician Stress

NCT07220421 · Burnout, Professional, Stress, Psychological, Stress, Physiological
Recruiting

This is a prospective, randomized, controlled clinical trial in which clinicians from University of Pennsylvania Health Systems (UPHS) including Penn Medicine- Lancaster General Health (LGH) and Massachusetts General Hospital (MGH) are offered a well-known program to help reduce clinician burnout: Sudarshan Kriya Yoga (SKY) Breathing and Sahaj Meditation Intervention.

PhaseNA
TypeInterventional
Age25 Years – 70 Years
WhereBoston, Massachusetts, United States + 5 more
SponsorLancaster General Hospital
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Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency

NCT04789148 · Vasopressin Deficiency
Recruiting

This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (6 IU and 24 IU) vs. placebo in adult men and women (aged 18 years and above) with arginine-vasopressin deficiency to evaluate the effect of oxytocin on anxiety, depression, and socioemotional functioning (Part A), with an optional randomized, double-blind, placebo-controlled 2-week repeated dose substudy of intranasal oxytocin 6 IU or placebo (Part B). Following a screening visit to determine eligibility, participants will return for three main study visits in Part A. During the main study visits, study participants will receive either oxytocin or placebo, followed by assessments of emotional behavior. In Part A, thirty participants will be equally randomized to one of six possible groups: 1. 6 IU oxytocin - 24 IU oxytocin - placebo 2. 6 IU oxytocin - placebo - 24 IU oxytocin 3. 24 IU oxytocin - 6 IU oxytocin - placebo 4. 24 IU oxytocin - placebo - 6 IU oxytocin 5. placebo - 6 IU oxytocin - 24 IU oxytocin 6. placebo - 24 IU oxytocin - 6 IU oxytocin Following completion of the Part A crossover portion of the study, in Part B participants may also choose to continue participation in an optional, randomized, double-blind, placebo-controlled substudy of intranasal oxytocin 6 IU or placebo three times a day for two weeks, followed by assessments of emotional behavior.

PhasePhase 1
TypeInterventional
Age18 Years
WhereBoston, Massachusetts, United States
SponsorElizabeth Austen Lawson
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RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

NCT07002034 · Adjustment Disorder
Recruiting

The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to cancer or other illnesses such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD) or Idiopathic Pulmonary Fibrosis (IPF) as compared to active-placebo.

PhasePhase 2
TypeInterventional
Age18 Years – 80 Years
WhereBirmingham, Alabama, United States + 29 more
SponsorReunion Neuroscience Inc
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Building Connections

NCT07091032 · Cancer Colorectal, Cancer Cervix, Depression, Anxiety
Recruiting

Building Connections seeks to address health and healthcare inequities in socially vulnerable communities. The project will be conducted in collaboration with clinical practices across Massachusetts, serving a diverse population heavily represented in Community Clinics and Health Centers. The program will offer evidence-based interventions in obesity/weight management, cancer screening, and mental health.

PhaseNA
TypeInterventional
Age18 Years – 75 Years
WhereBoston, Massachusetts, United States
SponsorMassachusetts General Hospital
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A Study of NTX-1472 in Social Anxiety Disorder

Recruiting

The primary goal of this Phase 2 clinical trial is to determine the effects of a novel V1a receptor antagonist (NTX-1472) in adults with Social Anxiety Disorder (SAD). The main questions this trial aims to answer are: * Is NTX-1472 safe and well tolerated in adults with SAD? * How effectively does NTX-1472 treat adults with SAD? Researchers will compare the effects of NTX-1472 with matching placebo (a look-alike capsule that contains no drug). Participants will: * Take NTX-1472 or matching placebo every day for 8 weeks * Visit the clinic 6 times over the course of 14 weeks for checkups and tests

PhasePhase 2
TypeInterventional
Age18 Years – 65 Years
WherePheonix, Arizona, United States + 10 more
SponsorNewleos Therapeutics, Inc.
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Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression

NCT05734313 · Diabetes, Type 1 Diabetes
Recruiting

This project will evaluate a telemedicine-delivered, Unified Protocol for Cognitive-Behavioral Therapy (UP-CBT) enhanced with continuous glucose monitor (CGM) review to target anxiety and depressive symptoms and glycemic control in adults with type 1 diabetes.

PhaseNA
TypeInterventional
Age18 Years – 64 Years
WhereBoston, Massachusetts, United States + 1 more
SponsorAlbert Einstein College of Medicine
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Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder

Recruiting

This is a multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of ITI-1284 as monotherapy treatment in patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for GAD in patients who have had inadequate response to generalized anxiety disorder treatment.

PhasePhase 2
TypeInterventional
Age18 Years
WhereBirmingham, Alabama, United States + 59 more
SponsorIntra-Cellular Therapies, Inc.
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Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

NCT07143357 · Emotional Distress, Cardiac Arrest (CA), Anxiety
Recruiting

The purpose of this study is to pilot two resilience interventions for cardiac arrest survivors and their informal caregivers, Recovering Together after Cardiac Arrest 1 and Recovering Together after Cardiac Arrest 2 . The data the investigators gather in this study will be used to further refine the interventions.

PhaseNA
TypeInterventional
Age18 Years
WhereBoston, Massachusetts, United States
SponsorMassachusetts General Hospital
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Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer

NCT06038318 · Stress, Anxiety
Recruiting

The goal of this study is to find the best way to help participants and families manage the stress of facing a serious illness and be better able to "bounce back" or be resilient after a difficult situation. Participants will take part in the "Promoting Resilience in Stress Management" PRISM program, which is designed to provide skills to change or improve the impact of stress in everyday life. The name of the intervention used in this research study is: -PRISM (a mobile app program comprised of 6 sessions of skills-based, manualized resilience education)

PhaseNA
TypeInterventional
Age12 Years – 25 Years
WhereBoston, Massachusetts, United States + 1 more
SponsorDana-Farber Cancer Institute
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Expressive Writing on Minority Stressors Among Sexual Minority Veterans

NCT05897021 · Depressive Symptoms, Anxiety
Recruiting

Sexual minority stressors (e.g., sexual minority identity-based discrimination) contribute to greater risk for and severity of depression, anxiety, substance use disorders and suicide among sexual minority Veterans. However, no brief, scalable, one-on-one interventions targeting sexual minority stressor-related distress are available in Veterans Affairs (VA) for sexual minority Veterans. The proposed research will examine the feasibility, acceptability, and preliminary effectiveness of a brief, 3-session expressive writing intervention to target distress related to sexual minority stressor exposure among sexual minority Veterans. The results of this work will advance knowledge about a promising brief and easy to implement intervention focused on reducing depressive and anxiety symptoms among sexual minority Veterans. This proposal aligns with VA's and CSR\&D's commitment to providing equitable services to sexual minority Veterans and the aim of reducing health disparities among underserved Veteran groups.

PhaseNA
TypeInterventional
Age18 Years
WhereBoston, Massachusetts, United States
SponsorVA Office of Research and Development
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Music Use in Parturients Admitted to Labor & Delivery

NCT06969105 · Anxiety, Pain, Patient Satisfaction
Recruiting

The goal of this clinical trial is to learn if music use affects anxiety or pain levels in parturients admitted to labor and delivery. It will also learn about the effect of music use on patient satisfaction. The main questions it aims to answer are: Does music use affect anxiety levels in parturients admitted to labor and delivery? Does music use affect pain levels in parturients admitted to labor and delivery? Does music use affect patient satisfaction in parturients admitted to labor and delivery? Researchers will compare music to a control (no music) to see if music affects anxiety levels in parturients admitted to labor and delivery. Participants will: Listen to music or listen to no music for a 10 minute duration in the labor and delivery unit. Answer questions about anxiety and pain levels at a few different timepoints. Have information collected from medical charts (vital signs and cervical dilation). Rate their satisfaction with care.

PhaseNA
TypeInterventional
Age18 Years
WhereBoston, Massachusetts, United States
SponsorTufts Medical Center
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Breaking Silence Through Story: A Narrative Medicine Intervention for Parents of Children With Urogenital Conditions

NCT06989593 · DSD, Hypospadias
Recruiting

The goal of this clinical trial is to learn whether a journaling intervention can reduce stress and anxiety in parents of children with urogenital conditions (such as differences of sex development and hypospadias). The main questions it aims to answer are: * Does guided journaling help to reduce anxiety levels in parents of children with urogenital conditions? * What are parents' perspectives on group-based writing interventions for future support programs? Participants will: * Complete a short anxiety questionnaire (the General Anxiety Disorder-7 scale) at the beginning of the study * Receive a physical journal with 5 writing prompts designed to help process emotions related to their child's condition * Complete 5 journal entries over several weeks, writing about their experiences and feelings * Complete the same anxiety questionnaire again after finishing the journal entries * Participate in a 45-minute interview to discuss how the journaling affected their stress levels and gather feedback on potential group-based writing programs

PhaseNA
TypeInterventional
Age18 Years
WhereBoston, Massachusetts, United States
SponsorSarah Schlegel
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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

NCT05962879 · Anxiety Disorders, Psychotic Disorders, Depressive Disorder
Recruiting

This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.

PhaseNA
TypeInterventional
Age14 Years – 19 Years
WhereBoston, Massachusetts, United States
SponsorMassachusetts General Hospital
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Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

NCT06812247 · Trauma Injury, Depression, Anxiety
Recruiting

Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer, post-traumatic stress disorder, and depression. Studies have also demonstrated that even in healthy adults, the presence of dogs is associated with physiologic changes such as increased pain threshold, decreased blood pressure, and decreased heart rate. However, few studies have investigated the role of AAT in the post-operative course in adults. This study will investigate the impact of therapy dog visits on pain and anxiety scores for trauma patients at Boston Medical Center (BMC).

PhaseNA
TypeInterventional
Age18 Years
WhereBoston, Massachusetts, United States
SponsorBoston Medical Center
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Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II

Recruiting

This study is a clinical trial that evaluates what drives patient engagement and tests the impact of two strategies-automated motivational push messaging and coach support-to improve engagement with an evidence-based mobile app intervention for depression and/or anxiety.

PhaseNA
TypeInterventional
Age18 Years – 75 Years
WhereBoston, Massachusetts, United States
SponsorBrigham and Women's Hospital
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Positive Minds Strong Joints for Knee Osteoarthritis

NCT06493903 · Osteoarthritis, Knee
Recruiting

The aim of this research study is to test the feasibility of a physical and mental health intervention (Positive Minds, Strong Joints or PMSJ) for Black adults with knee osteoarthritis (OA).

PhaseNA
TypeInterventional
Age50 Years
WhereBoston, Massachusetts, United States
SponsorBoston University Charles River Campus
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Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

NCT06557005 · Hypertension, Diabetes, Postpartum
Recruiting

The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the \>30% of pregnant people who have or are at risk for these conditions. This study aims to increase postpartum primary care engagement, quality, and experience by strengthening postpartum transitions to primary care using a behavioral economics-informed, multi-component intervention integrated into usual inpatient postpartum care. Using a randomized controlled trial and repeated outcome assessments through administrative and survey data, this study will generate rigorous, actionable evidence to ensure primary care coordination becomes standard postpartum care practice, potentially catalyzing sustained primary care engagement throughout life.

PhaseNA
TypeInterventional
Age18 Years
WhereBoston, Massachusetts, United States
SponsorMassachusetts General Hospital
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CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

NCT05467683 · Obsessive-Compulsive Disorder, Post Traumatic Stress Disorder, Generalized Anxiety Disorder
Recruiting

Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question "can this easy-to-administer assay aid clinicians in deciding whether or not to initiate exposure-based therapy?"

PhaseNA
TypeInterventional
Age18 Years – 70 Years
WhereBoston, Massachusetts, United States + 1 more
SponsorUniversity of Texas at Austin
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Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

NCT06376734 · Major Depressive Disorder, Obsessive-Compulsive Disorder, Schizophrenia
Recruiting

Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.

PhasePhase 2
TypeInterventional
Age18 Years – 65 Years
WhereSunnyvale, California, United States + 1 more
SponsorBrigham and Women's Hospital
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Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

Recruiting

This is a multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of ITI-1284 compared with placebo as adjunctive therapy to GAD treatment in patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for GAD who have an inadequate response to ongoing GAD treatment.

PhasePhase 2
TypeInterventional
Age18 Years
WhereChandler, Arizona, United States + 68 more
SponsorIntra-Cellular Therapies, Inc.
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